Transcription factors with Perturb-seq knockdown data for ENSG00000284607. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000284607 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000284607, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:26,568,696–26,568,967 | 355 bp | At TSS | 738 | |
| chr6:26,569,200–26,569,380 | at TSS | At TSS | 307 | |
| chr6:26,571,613–26,572,233 | 2.3 kb | Proximal (<10kb) | 861 | |
| chr6:26,572,442–26,573,062 | 3.1 kb | Proximal (<10kb) | 414 | |
| chr6:26,575,547–26,575,908 | 6.2 kb | Proximal (<10kb) | 240 | |
| chr6:26,577,046–26,577,262 | 7.7 kb | Proximal (<10kb) | 443 |
Genomic view of the ENSG00000284607 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.