Transcription factors with Perturb-seq knockdown data for ENSG00000283913. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000283913 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000283913, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:79,904,553–79,905,313 | 29 bp | At TSS Multiome | 317 | |
| chr10:79,981,449–79,982,593 | 77.2 kb | Distal (>10kb) Multiome | 420 | |
| chr10:80,076,334–80,077,082 | 171.7 kb | Distal (>10kb) Multiome | 10 | |
| chr10:80,078,334–80,079,521 | 174.1 kb | Distal (>10kb) Multiome | 806 | |
| chr10:80,132,279–80,133,011 | 227.7 kb | Distal (>10kb) Multiome | 155 |
Genomic view of the ENSG00000283913 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.