Transcription factors with Perturb-seq knockdown data for ENSG00000283480. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000283480 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000283480, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:21,586,889–21,589,570 | 6.0 kb | Proximal (<10kb) | 917 | |
| chr6:21,593,301–21,595,945 | at TSS | At TSS | 834 | |
| chr6:21,596,125–21,596,441 | 532 bp | At TSS | 289 | |
| chr6:21,596,549–21,596,984 | 956 bp | At TSS | 373 | |
| chr6:21,601,865–21,602,374 | 6.3 kb | Proximal (<10kb) | 104 |
Genomic view of the ENSG00000283480 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.