Transcription factors with Perturb-seq knockdown data for ENSG00000283235. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000283235 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000283235, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:176,172,154–176,172,641 | 26.7 kb | Distal (>10kb) Multiome | 15 | |
| chr5:176,183,360–176,184,067 | 15.5 kb | Distal (>10kb) Multiome | 165 | |
| chr5:176,197,313–176,197,739 | 1.6 kb | Proximal (<10kb) | 133 | |
| chr5:176,199,317–176,199,686 | 22 bp | At TSS | 43 | |
| chr5:176,361,095–176,362,133 | 162.4 kb | Distal (>10kb) Multiome | 877 | |
| chr5:176,365,184–176,366,532 | 166.2 kb | Distal (>10kb) Multiome | 352 | |
| chr5:176,388,019–176,389,614 | 189.7 kb | Distal (>10kb) Multiome | 1052 | |
| chr5:176,415,859–176,416,971 | 217.3 kb | Distal (>10kb) Multiome | 827 | |
| chr5:176,441,967–176,442,454 | 242.9 kb | Distal (>10kb) Multiome | 166 | |
| chr5:176,447,162–176,449,016 | 248.9 kb | Distal (>10kb) Multiome | 859 |
Genomic view of the ENSG00000283235 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.