Transcription factors with Perturb-seq knockdown data for ENSG00000282024. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000282024 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000282024, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:16,128,529–16,130,130 | 133.9 kb | Distal (>10kb) Multiome | 1070 | |
| chr6:16,174,497–16,175,068 | 88.1 kb | Distal (>10kb) Multiome | 94 | |
| chr6:16,238,170–16,238,814 | 24.4 kb | Distal (>10kb) Multiome | 433 | |
| chr6:16,256,456–16,257,142 | 5.8 kb | Proximal (<10kb) | 48 | |
| chr6:16,258,262–16,258,637 | 4.3 kb | Proximal (<10kb) | 108 | |
| chr6:16,259,093–16,259,403 | 3.5 kb | Proximal (<10kb) | 9 | |
| chr6:16,262,868–16,263,186 | at TSS | At TSS | 41 | |
| chr6:16,264,333–16,265,125 | 1.4 kb | Proximal (<10kb) | 25 | |
| chr6:16,331,420–16,332,565 | 69.3 kb | Distal (>10kb) Multiome | 498 |
Genomic view of the ENSG00000282024 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.