Transcription factors with Perturb-seq knockdown data for ENSG00000280087. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000280087 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000280087, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:44,903,686–44,904,241 | 5.1 kb | Proximal (<10kb) | 666 | |
| chr19:44,905,114–44,907,037 | 2.3 kb | Proximal (<10kb) | 645 | |
| chr19:44,909,850–44,910,571 | 476 bp | At TSS | 146 | |
| chr19:44,911,026–44,911,489 | 1.7 kb | Proximal (<10kb) | 533 | |
| chr19:44,913,546–44,915,671 | 4.2 kb | Proximal (<10kb) | 587 |
Genomic view of the ENSG00000280087 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.