Transcription factors with Perturb-seq knockdown data for ENSG00000278254. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000278254 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000278254, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:9,179,557–9,180,970 | 8.9 kb | Proximal (<10kb) | 25 | |
| chr7:9,181,921–9,182,144 | 7.7 kb | Proximal (<10kb) | 9 | |
| chr7:9,189,503–9,190,083 | at TSS | At TSS | 36 | |
| chr7:9,204,043–9,205,229 | 14.9 kb | Distal (>10kb) Multiome | 240 | |
| chr7:10,939,396–10,941,296 | 1750.6 kb | Distal (>10kb) Multiome HiCAR | 1007 |
Genomic view of the ENSG00000278254 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.