Transcription factors with Perturb-seq knockdown data for ENSG00000277463. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000277463 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000277463, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:62,423,543–62,424,436 | 202.1 kb | Distal (>10kb) Multiome | 604 | |
| chr17:62,477,989–62,479,448 | 147.4 kb | Distal (>10kb) Multiome | 323 | |
| chr17:62,617,005–62,618,105 | 8.6 kb | Proximal (<10kb) Multiome | 481 | |
| chr17:62,625,629–62,626,248 | at TSS | At TSS | 60 | |
| chr17:62,626,684–62,628,608 | 1.4 kb | Proximal (<10kb) Multiome | 557 | |
| chr17:62,628,899–62,629,683 | 2.9 kb | Proximal (<10kb) | 135 | |
| chr17:62,633,691–62,633,854 | 7.7 kb | Proximal (<10kb) | 102 | |
| chr17:62,652,264–62,654,102 | 27.3 kb | Distal (>10kb) Multiome | 643 | |
| chr17:62,703,431–62,705,528 | 78.0 kb | Distal (>10kb) Multiome | 653 | |
| chr17:62,705,630–62,706,390 | 79.9 kb | Distal (>10kb) Multiome | 153 | |
| chr17:62,807,913–62,808,572 | 182.3 kb | Distal (>10kb) Multiome | 313 |
Genomic view of the ENSG00000277463 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.