Transcription factors with Perturb-seq knockdown data for ENSG00000277342. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000277342 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000277342, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:31,958,831–31,959,907 | 149.7 kb | Distal (>10kb) Multiome | 866 | |
| chr12:32,016,824–32,017,328 | 91.9 kb | Distal (>10kb) Multiome | 159 | |
| chr12:32,022,349–32,022,802 | 86.5 kb | Distal (>10kb) Multiome | 56 | |
| chr12:32,106,218–32,107,295 | 2.3 kb | Proximal (<10kb) Multiome | 874 | |
| chr12:32,139,428–32,140,190 | 30.9 kb | Distal (>10kb) Multiome | 274 | |
| chr12:32,398,922–32,400,774 | 290.5 kb | Distal (>10kb) Multiome | 832 |
Genomic view of the ENSG00000277342 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.