Transcription factors with Perturb-seq knockdown data for ENSG00000276727. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000276727 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000276727, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:57,224,526–57,225,152 | 5.0 kb | Proximal (<10kb) | 267 | |
| chr12:57,225,987–57,227,617 | 2.6 kb | Proximal (<10kb) | 236 | |
| chr12:57,229,358–57,230,407 | at TSS | At TSS | 739 | |
| chr12:57,234,986–57,235,550 | 4.8 kb | Proximal (<10kb) | 365 | |
| chr12:57,236,204–57,236,680 | 6.0 kb | Proximal (<10kb) | 133 | |
| chr12:57,237,027–57,237,584 | 6.8 kb | Proximal (<10kb) | 93 | |
| chr12:57,237,805–57,241,749 | 7.6 kb | Proximal (<10kb) | 846 |
Genomic view of the ENSG00000276727 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.