Transcription factors with Perturb-seq knockdown data for ENSG00000276528. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000276528 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000276528, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:27,087,824–27,088,552 | 7.6 kb | Proximal (<10kb) | 142 | |
| chr7:27,091,885–27,092,537 | 3.6 kb | Proximal (<10kb) | 166 | |
| chr7:27,094,336–27,094,532 | 1.6 kb | Proximal (<10kb) | 29 | |
| chr7:27,095,780–27,096,930 | at TSS | At TSS | 507 | |
| chr7:27,098,275–27,098,615 | 2.2 kb | Proximal (<10kb) | 146 | |
| chr7:27,102,914–27,103,245 | 6.8 kb | Proximal (<10kb) | 92 |
Genomic view of the ENSG00000276528 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.