Transcription factors with Perturb-seq knockdown data for ENSG00000275964. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000275964 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000275964, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr13:19,601,659–19,602,741 | 261.8 kb | Distal (>10kb) Multiome | 619 | |
| chr13:19,633,184–19,634,576 | 230.3 kb | Distal (>10kb) Multiome | 757 | |
| chr13:19,782,029–19,783,375 | 80.9 kb | Distal (>10kb) Multiome | 684 | |
| chr13:19,862,481–19,865,034 | 138 bp | At TSS Multiome | 795 | |
| chr13:19,957,304–19,960,590 | 93.6 kb | Distal (>10kb) Multiome | 820 | |
| chr13:20,118,252–20,119,428 | 254.6 kb | Distal (>10kb) Multiome | 466 | |
| chr13:20,120,417–20,121,025 | 256.8 kb | Distal (>10kb) Multiome | 261 | |
| chr13:20,127,350–20,128,944 | 264.1 kb | Distal (>10kb) Multiome | 711 | |
| chr13:20,160,373–20,161,681 | 297.2 kb | Distal (>10kb) Multiome | 387 |
Genomic view of the ENSG00000275964 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.