Transcription factors with Perturb-seq knockdown data for ENSG00000273489. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000273489 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000273489, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:131,327,222–131,328,641 | 169.8 kb | Distal (>10kb) Multiome | 963 | |
| chr7:131,546,665–131,547,151 | 49.2 kb | Distal (>10kb) Multiome | 202 | |
| chr7:131,556,063–131,558,394 | 59.0 kb | Distal (>10kb) Multiome | 671 | |
| chr7:131,604,843–131,605,922 | 107.7 kb | Distal (>10kb) Multiome | 273 | |
| chr7:131,625,703–131,626,457 | 128.4 kb | Distal (>10kb) Multiome | 315 | |
| chr7:131,654,727–131,655,304 | 157.2 kb | Distal (>10kb) Multiome | 306 | |
| chr7:131,691,912–131,692,612 | 194.6 kb | Distal (>10kb) Multiome | 352 |
Genomic view of the ENSG00000273489 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.