Transcription factors with Perturb-seq knockdown data for ENSG00000273329. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000273329 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000273329, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:129,433,659–129,435,261 | 177.3 kb | Distal (>10kb) Multiome | 770 | |
| chr7:129,453,732–129,454,848 | 157.3 kb | Distal (>10kb) Multiome | 197 | |
| chr7:129,502,098–129,503,287 | 109.2 kb | Distal (>10kb) Multiome | 480 | |
| chr7:129,607,861–129,608,034 | 3.6 kb | Proximal (<10kb) | 77 | |
| chr7:129,611,327–129,612,516 | 49 bp | At TSS Multiome | 882 | |
| chr7:129,775,743–129,776,961 | 164.9 kb | Distal (>10kb) Multiome | 77 | |
| chr7:129,778,637–129,782,868 | 168.6 kb | Distal (>10kb) Multiome | 821 | |
| chr7:129,824,642–129,826,481 | 214.2 kb | Distal (>10kb) Multiome | 809 | |
| chr7:129,829,901–129,830,704 | 218.6 kb | Distal (>10kb) Multiome | 440 |
Genomic view of the ENSG00000273329 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.