Transcription factors with Perturb-seq knockdown data for ENSG00000273162. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000273162 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000273162, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:100,912,455–100,913,519 | 148.1 kb | Distal (>10kb) Multiome | 906 | |
| chr10:100,968,950–100,970,567 | 91.6 kb | Distal (>10kb) Multiome | 681 | |
| chr10:100,987,003–100,987,794 | 73.5 kb | Distal (>10kb) Multiome | 786 | |
| chr10:100,996,424–100,998,696 | 64.1 kb | Distal (>10kb) Multiome | 945 | |
| chr10:100,998,810–101,000,165 | 61.4 kb | Distal (>10kb) Multiome | 845 | |
| chr10:101,018,377–101,019,461 | 41.9 kb | Distal (>10kb) Multiome | 654 | |
| chr10:101,030,588–101,032,521 | 29.8 kb | Distal (>10kb) Multiome | 613 | |
| chr10:101,042,527–101,043,387 | 18.1 kb | Distal (>10kb) Multiome | 655 | |
| chr10:101,048,051–101,048,547 | 12.7 kb | Distal (>10kb) Multiome | 87 | |
| chr10:101,049,966–101,050,753 | 10.6 kb | Distal (>10kb) Multiome | 412 | |
| chr10:101,060,073–101,063,211 | 1.8 kb | Proximal (<10kb) Multiome | 1124 | |
| chr10:101,066,181–101,066,983 | 5.5 kb | Proximal (<10kb) Multiome | 734 | |
| chr10:101,067,105–101,068,123 | 6.9 kb | Proximal (<10kb) Multiome | 643 | |
| chr10:101,095,368–101,096,269 | 34.7 kb | Distal (>10kb) Multiome | 326 | |
| chr10:101,131,094–101,132,387 | 70.3 kb | Distal (>10kb) Multiome | 289 | |
| chr10:101,139,407–101,140,520 | 78.8 kb | Distal (>10kb) Multiome | 158 | |
| chr10:101,161,678–101,162,270 | 100.9 kb | Distal (>10kb) Multiome | 336 | |
| chr10:101,214,601–101,215,378 | 154.0 kb | Distal (>10kb) Multiome | 302 | |
| chr10:101,217,392–101,218,117 | 156.7 kb | Distal (>10kb) Multiome | 203 | |
| chr10:101,236,527–101,237,332 | 176.0 kb | Distal (>10kb) Multiome | 123 | |
| chr10:101,285,534–101,286,046 | 224.9 kb | Distal (>10kb) Multiome | 150 | |
| chr10:101,291,317–101,293,346 | 230.8 kb | Distal (>10kb) Multiome | 433 | |
| chr10:101,311,194–101,311,678 | 250.3 kb | Distal (>10kb) Multiome | 94 | |
| chr10:101,353,481–101,354,935 | 293.0 kb | Distal (>10kb) Multiome | 875 |
Genomic view of the ENSG00000273162 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.