Transcription factors with Perturb-seq knockdown data for ENSG00000272438. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000272438 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000272438, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:904,256–904,920 | 88 bp | At TSS Multiome | 590 | |
| chr1:923,612–925,339 | 19.0 kb | Distal (>10kb) Multiome | 500 | |
| chr1:939,835–943,080 | 37.1 kb | Distal (>10kb) Multiome | 864 | |
| chr1:959,035–960,017 | 54.5 kb | Distal (>10kb) Multiome | 622 | |
| chr1:960,291–961,429 | 55.9 kb | Distal (>10kb) Multiome | 552 | |
| chr1:975,960–976,521 | 71.4 kb | Distal (>10kb) Multiome | 476 | |
| chr1:998,350–1,000,999 | 95.5 kb | Distal (>10kb) Multiome | 1047 | |
| chr1:1,001,349–1,002,099 | 97.2 kb | Distal (>10kb) Multiome | 646 | |
| chr1:1,005,015–1,005,702 | 100.4 kb | Distal (>10kb) Multiome | 532 | |
| chr1:1,019,142–1,021,414 | 114.8 kb | Distal (>10kb) Multiome | 707 | |
| chr1:1,032,438–1,034,753 | 128.4 kb | Distal (>10kb) Multiome | 475 | |
| chr1:1,040,071–1,041,597 | 136.1 kb | Distal (>10kb) Multiome | 410 | |
| chr1:1,058,856–1,060,114 | 154.7 kb | Distal (>10kb) Multiome | 609 | |
| chr1:1,068,556–1,069,991 | 164.4 kb | Distal (>10kb) Multiome | 577 | |
| chr1:1,079,478–1,080,558 | 175.2 kb | Distal (>10kb) Multiome | 746 | |
| chr1:1,115,769–1,117,022 | 211.4 kb | Distal (>10kb) Multiome | 743 | |
| chr1:1,157,424–1,158,362 | 252.7 kb | Distal (>10kb) Multiome | 575 | |
| chr1:1,200,907–1,201,739 | 296.6 kb | Distal (>10kb) Multiome | 430 |
Genomic view of the ENSG00000272438 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.