Transcription factors with Perturb-seq knockdown data for ENSG00000272030. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000272030 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000272030, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:153,494,904–153,495,543 | 139.3 kb | Distal (>10kb) Multiome | 290 | |
| chr1:153,532,833–153,533,594 | 101.2 kb | Distal (>10kb) Multiome | 493 | |
| chr1:153,538,198–153,538,657 | 95.9 kb | Distal (>10kb) Multiome | 338 | |
| chr1:153,544,844–153,545,543 | 89.2 kb | Distal (>10kb) Multiome | 575 | |
| chr1:153,568,278–153,569,058 | 65.7 kb | Distal (>10kb) Multiome | 641 | |
| chr1:153,626,535–153,627,974 | 6.8 kb | Proximal (<10kb) Multiome | 697 | |
| chr1:153,633,575–153,634,639 | 367 bp | At TSS Multiome | 998 | |
| chr1:153,658,331–153,659,230 | 24.3 kb | Distal (>10kb) Multiome | 746 | |
| chr1:153,670,709–153,671,992 | 36.8 kb | Distal (>10kb) Multiome | 884 | |
| chr1:153,697,776–153,698,654 | 63.9 kb | Distal (>10kb) Multiome | 313 | |
| chr1:153,727,492–153,728,827 | 93.5 kb | Distal (>10kb) Multiome | 702 | |
| chr1:153,745,487–153,745,959 | 111.3 kb | Distal (>10kb) Multiome | 55 | |
| chr1:153,774,962–153,776,698 | 141.7 kb | Distal (>10kb) Multiome | 671 | |
| chr1:153,783,341–153,784,300 | 149.3 kb | Distal (>10kb) Multiome | 794 | |
| chr1:153,922,213–153,923,779 | 288.7 kb | Distal (>10kb) Multiome | 856 |
Genomic view of the ENSG00000272030 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.