Transcription factors with Perturb-seq knockdown data for ENSG00000271776. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000271776 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000271776, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr13:78,586,435–78,587,075 | 9.1 kb | Proximal (<10kb) | 145 | |
| chr13:78,589,321–78,589,513 | 6.6 kb | Proximal (<10kb) | 218 | |
| chr13:78,593,896–78,594,535 | 1.6 kb | Proximal (<10kb) | 145 | |
| chr13:78,595,488–78,596,692 | at TSS | At TSS | 312 | |
| chr13:78,597,128–78,597,471 | 1.0 kb | At TSS | 86 | |
| chr13:78,601,064–78,602,096 | 4.9 kb | Proximal (<10kb) | 114 | |
| chr13:78,602,275–78,603,984 | 6.1 kb | Proximal (<10kb) | 557 | |
| chr13:78,605,182–78,605,825 | 9.1 kb | Proximal (<10kb) | 185 |
Genomic view of the ENSG00000271776 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.