Transcription factors with Perturb-seq knockdown data for ENSG00000271732. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000271732 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000271732, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:16,612,236–16,614,194 | 3.2 kb | Proximal (<10kb) | 1105 | |
| chr1:16,614,369–16,614,937 | 2.5 kb | Proximal (<10kb) | 205 | |
| chr1:16,616,946–16,617,402 | at TSS | At TSS | 163 | |
| chr1:16,618,793–16,619,020 | 1.4 kb | Proximal (<10kb) | 66 | |
| chr1:16,620,707–16,621,639 | 3.3 kb | Proximal (<10kb) | 685 | |
| chr1:16,624,991–16,625,212 | 7.6 kb | Proximal (<10kb) | 296 | |
| chr1:16,625,677–16,626,186 | 8.3 kb | Proximal (<10kb) | 244 |
Genomic view of the ENSG00000271732 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.