Transcription factors with Perturb-seq knockdown data for ENSG00000271252. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000271252 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000271252, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:95,741,225–95,741,626 | 1.5 kb | Proximal (<10kb) | 5 | |
| chr1:95,742,286–95,743,852 | at TSS | At TSS | 260 | |
| chr1:95,744,307–95,744,432 | 1.2 kb | Proximal (<10kb) | 5 | |
| chr1:95,744,525–95,744,873 | 1.4 kb | Proximal (<10kb) | 22 |
Genomic view of the ENSG00000271252 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.