Transcription factors with Perturb-seq knockdown data for ENSG00000270179. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000270179 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000270179, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:113,361,033–113,361,386 | 7.1 kb | Proximal (<10kb) | 11 | |
| chr11:113,369,396–113,370,492 | 918 bp | At TSS | 121 | |
| chr11:113,373,996–113,374,247 | 5.5 kb | Proximal (<10kb) | 78 | |
| chr11:113,375,504–113,376,133 | 7.0 kb | Proximal (<10kb) | 34 | |
| chr11:113,376,850–113,377,697 | 8.4 kb | Proximal (<10kb) | 24 |
Genomic view of the ENSG00000270179 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.