Transcription factors with Perturb-seq knockdown data for ENSG00000269934. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000269934 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000269934, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:228,004,351–228,004,883 | 271.5 kb | Distal (>10kb) Multiome | 154 | |
| chr1:228,058,680–228,061,126 | 216.2 kb | Distal (>10kb) Multiome | 377 | |
| chr1:228,081,634–228,083,952 | 193.4 kb | Distal (>10kb) Multiome | 942 | |
| chr1:228,085,140–228,085,832 | 190.6 kb | Distal (>10kb) Multiome | 276 | |
| chr1:228,101,882–228,103,743 | 173.8 kb | Distal (>10kb) Multiome | 929 | |
| chr1:228,108,924–228,110,105 | 166.6 kb | Distal (>10kb) Multiome | 958 | |
| chr1:228,130,684–228,131,457 | 145.0 kb | Distal (>10kb) Multiome | 488 | |
| chr1:228,139,579–228,140,870 | 135.9 kb | Distal (>10kb) Multiome | 931 | |
| chr1:228,164,898–228,166,840 | 110.2 kb | Distal (>10kb) Multiome | 1011 | |
| chr1:228,174,477–228,174,893 | 101.4 kb | Distal (>10kb) Multiome | 254 | |
| chr1:228,212,247–228,214,390 | 62.4 kb | Distal (>10kb) Multiome | 604 | |
| chr1:228,275,524–228,276,595 | 37 bp | At TSS Multiome | 428 | |
| chr1:228,378,133–228,379,597 | 102.6 kb | Distal (>10kb) Multiome | 515 | |
| chr1:228,406,106–228,407,568 | 131.0 kb | Distal (>10kb) Multiome | 753 | |
| chr1:228,416,050–228,416,929 | 140.5 kb | Distal (>10kb) Multiome | 279 | |
| chr1:228,457,070–228,458,723 | 181.8 kb | Distal (>10kb) Multiome | 800 | |
| chr1:228,458,870–228,459,670 | 183.3 kb | Distal (>10kb) Multiome | 503 | |
| chr1:228,464,228–228,465,055 | 188.7 kb | Distal (>10kb) Multiome | 204 | |
| chr1:228,486,589–228,487,963 | 211.2 kb | Distal (>10kb) Multiome | 1041 |
Genomic view of the ENSG00000269934 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.