TFs regulating ENSG00000268649 0 TFs

Transcription factors with Perturb-seq knockdown data for ENSG00000268649. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000268649 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to ENSG00000268649

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000268649, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr20:57,389,119–57,389,876	1428.3 kb	Distal (>10kb) Multiome HiCAR	590
chr20:58,523,004–58,524,066	294.3 kb	Distal (>10kb) Multiome	197
chr20:58,546,673–58,547,327	270.7 kb	Distal (>10kb) Multiome	69
chr20:58,649,950–58,652,788	166.6 kb	Distal (>10kb) Multiome	1208
chr20:58,669,288–58,669,967	148.1 kb	Distal (>10kb) Multiome	158
chr20:58,692,413–58,693,477	125.0 kb	Distal (>10kb) Multiome	317
chr20:58,850,471–58,851,960	33.2 kb	Distal (>10kb) Multiome	308
chr20:58,852,406–58,852,990	35.1 kb	Distal (>10kb) Multiome	172
chr20:58,888,196–58,892,842	71.3 kb	Distal (>10kb) Multiome	977
chr20:58,980,774–58,981,785	163.5 kb	Distal (>10kb) Multiome	797
chr20:59,006,785–59,007,608	189.5 kb	Distal (>10kb) Multiome	401
chr20:59,031,825–59,033,029	214.7 kb	Distal (>10kb) Multiome	1108
chr20:59,042,196–59,043,527	225.2 kb	Distal (>10kb) Multiome	834

Genome Browser

Genomic view of the ENSG00000268649 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.