Transcription factors with Perturb-seq knockdown data for ENSG00000268205. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000268205 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000268205, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:55,674,767–55,675,613 | 1629.1 kb | Distal (>10kb) Multiome HiCAR | 765 | |
| chr19:57,191,186–57,191,993 | 112.8 kb | Distal (>10kb) Multiome | 712 | |
| chr19:57,240,050–57,241,126 | 63.7 kb | Distal (>10kb) Multiome | 809 | |
| chr19:57,279,622–57,281,023 | 24.0 kb | Distal (>10kb) Multiome | 1026 | |
| chr19:57,320,108–57,321,075 | 16.2 kb | Distal (>10kb) Multiome | 668 | |
| chr19:57,350,874–57,351,693 | 46.9 kb | Distal (>10kb) Multiome | 620 | |
| chr19:57,362,957–57,363,972 | 59.1 kb | Distal (>10kb) Multiome | 697 | |
| chr19:57,389,420–57,390,542 | 85.6 kb | Distal (>10kb) Multiome | 722 | |
| chr19:57,410,944–57,411,658 | 106.8 kb | Distal (>10kb) Multiome | 612 | |
| chr19:57,434,797–57,436,077 | 131.1 kb | Distal (>10kb) Multiome | 742 | |
| chr19:57,477,251–57,477,789 | 173.3 kb | Distal (>10kb) Multiome | 582 | |
| chr19:57,487,570–57,488,036 | 183.5 kb | Distal (>10kb) Multiome | 483 | |
| chr19:57,499,726–57,500,208 | 195.6 kb | Distal (>10kb) Multiome | 523 | |
| chr19:57,527,148–57,527,898 | 223.1 kb | Distal (>10kb) Multiome | 711 | |
| chr19:57,559,528–57,559,978 | 255.5 kb | Distal (>10kb) Multiome | 564 | |
| chr19:57,578,473–57,579,216 | 274.7 kb | Distal (>10kb) Multiome | 668 | |
| chr19:57,583,416–57,584,426 | 279.7 kb | Distal (>10kb) Multiome | 462 | |
| chr19:57,599,699–57,600,175 | 295.6 kb | Distal (>10kb) Multiome | 646 | |
| chr19:58,150,278–58,150,941 | 846.4 kb | Distal (>10kb) Multiome HiCAR | 533 | |
| chr19:58,154,448–58,155,527 | 850.8 kb | Distal (>10kb) Multiome HiCAR | 802 |
Genomic view of the ENSG00000268205 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.