Transcription factors with Perturb-seq knockdown data for ENSG00000267723. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000267723 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000267723, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:14,005,474–14,007,363 | 286.7 kb | Distal (>10kb) Multiome | 1098 | |
| chr19:14,031,574–14,032,483 | 261.0 kb | Distal (>10kb) Multiome | 726 | |
| chr19:14,057,383–14,057,841 | 235.5 kb | Distal (>10kb) Multiome | 244 | |
| chr19:14,071,936–14,072,417 | 220.9 kb | Distal (>10kb) Multiome | 676 | |
| chr19:14,072,991–14,073,911 | 219.6 kb | Distal (>10kb) Multiome | 589 | |
| chr19:14,081,022–14,082,024 | 211.7 kb | Distal (>10kb) Multiome | 806 | |
| chr19:14,089,535–14,092,049 | 202.2 kb | Distal (>10kb) Multiome | 766 | |
| chr19:14,117,519–14,118,617 | 175.2 kb | Distal (>10kb) Multiome | 734 | |
| chr19:14,136,079–14,137,770 | 156.3 kb | Distal (>10kb) Multiome | 978 | |
| chr19:14,206,623–14,207,699 | 86.0 kb | Distal (>10kb) Multiome | 444 | |
| chr19:14,247,378–14,248,008 | 45.6 kb | Distal (>10kb) Multiome | 109 | |
| chr19:14,248,166–14,249,635 | 44.4 kb | Distal (>10kb) Multiome | 230 | |
| chr19:14,264,813–14,266,130 | 27.7 kb | Distal (>10kb) Multiome | 223 | |
| chr19:14,288,904–14,289,104 | 4.1 kb | Proximal (<10kb) | 24 | |
| chr19:14,293,536–14,293,885 | 331 bp | At TSS | 61 | |
| chr19:14,294,831–14,295,420 | 2.0 kb | Proximal (<10kb) Multiome | 60 | |
| chr19:14,363,590–14,364,020 | 70.5 kb | Distal (>10kb) Multiome | 402 | |
| chr19:14,405,442–14,406,893 | 113.0 kb | Distal (>10kb) Multiome | 662 | |
| chr19:14,418,847–14,419,795 | 126.2 kb | Distal (>10kb) Multiome | 817 | |
| chr19:14,432,848–14,433,780 | 140.1 kb | Distal (>10kb) Multiome | 524 | |
| chr19:14,450,232–14,451,000 | 157.4 kb | Distal (>10kb) Multiome | 271 | |
| chr19:14,472,177–14,472,986 | 179.3 kb | Distal (>10kb) Multiome | 566 | |
| chr19:14,495,705–14,496,690 | 203.1 kb | Distal (>10kb) Multiome | 813 | |
| chr19:14,517,523–14,519,160 | 225.4 kb | Distal (>10kb) Multiome | 952 | |
| chr19:14,528,857–14,530,279 | 236.3 kb | Distal (>10kb) Multiome | 842 | |
| chr19:14,536,700–14,537,683 | 244.0 kb | Distal (>10kb) Multiome | 329 | |
| chr19:14,556,545–14,557,088 | 263.6 kb | Distal (>10kb) Multiome | 509 | |
| chr19:14,564,060–14,565,155 | 271.3 kb | Distal (>10kb) Multiome | 226 | |
| chr19:14,571,772–14,572,330 | 278.9 kb | Distal (>10kb) Multiome | 896 |
Genomic view of the ENSG00000267723 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.