Transcription factors with Perturb-seq knockdown data for ENSG00000267284. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000267284 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000267284, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr18:55,322,133–55,322,873 | 267.5 kb | Distal (>10kb) Multiome | 382 | |
| chr18:55,438,990–55,439,594 | 150.7 kb | Distal (>10kb) Multiome | 111 | |
| chr18:55,466,657–55,467,846 | 122.9 kb | Distal (>10kb) Multiome | 159 | |
| chr18:55,572,972–55,573,887 | 16.3 kb | Distal (>10kb) Multiome | 122 | |
| chr18:55,582,376–55,582,628 | 7.3 kb | Proximal (<10kb) | 116 | |
| chr18:55,587,477–55,588,617 | 1.8 kb | Proximal (<10kb) Multiome | 353 | |
| chr18:55,589,695–55,590,485 | 17 bp | At TSS Multiome | 572 | |
| chr18:55,747,941–55,749,345 | 158.6 kb | Distal (>10kb) Multiome | 394 |
Genomic view of the ENSG00000267284 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.