TFs regulating ENSG00000267248 0 TFs

Transcription factors with Perturb-seq knockdown data for ENSG00000267248. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000267248 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to ENSG00000267248

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000267248, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr17:59,837,406–59,838,036	298.0 kb	Distal (>10kb) Multiome	865
chr17:59,892,295–59,893,854	242.6 kb	Distal (>10kb) Multiome	992
chr17:59,964,460–59,965,228	170.9 kb	Distal (>10kb) Multiome	834
chr17:60,037,145–60,037,598	98.4 kb	Distal (>10kb) Multiome	592
chr17:60,078,377–60,079,189	56.8 kb	Distal (>10kb) Multiome	765
chr17:60,135,208–60,135,905	6 bp	At TSS Multiome	832
chr17:60,139,659–60,140,250	4.0 kb	Proximal (<10kb)	847
chr17:60,142,132–60,142,546	6.6 kb	Proximal (<10kb) Multiome	250
chr17:60,142,949–60,143,382	7.4 kb	Proximal (<10kb) Multiome	395
chr17:60,327,303–60,327,917	192.0 kb	Distal (>10kb) Multiome	115
chr17:60,384,860–60,385,543	249.4 kb	Distal (>10kb) Multiome	76
chr17:60,391,203–60,392,936	256.5 kb	Distal (>10kb) Multiome	1085
chr17:60,421,283–60,422,169	286.0 kb	Distal (>10kb) Multiome HiCAR	479

Genome Browser

Genomic view of the ENSG00000267248 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.