Transcription factors with Perturb-seq knockdown data for ENSG00000267137. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000267137 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000267137, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:61,454,364–61,455,326 | 8.1 kb | Proximal (<10kb) | 441 | |
| chr17:61,456,171–61,456,729 | 6.7 kb | Proximal (<10kb) | 96 | |
| chr17:61,457,476–61,457,985 | 5.4 kb | Proximal (<10kb) | 74 | |
| chr17:61,461,961–61,462,715 | 668 bp | At TSS | 207 | |
| chr17:61,463,060–61,463,832 | at TSS | At TSS | 170 | |
| chr17:61,464,680–61,465,281 | 1.3 kb | Proximal (<10kb) | 80 | |
| chr17:61,467,469–61,467,894 | 4.1 kb | Proximal (<10kb) | 282 |
Genomic view of the ENSG00000267137 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.