Transcription factors with Perturb-seq knockdown data for ENSG00000266268. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000266268 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000266268, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr18:4,453,771–4,456,184 | 549.2 kb | Distal (>10kb) Multiome HiCAR | 344 | |
| chr18:4,704,346–4,705,607 | 299.5 kb | Distal (>10kb) Multiome | 145 | |
| chr18:4,813,533–4,814,481 | 190.6 kb | Distal (>10kb) Multiome | 95 | |
| chr18:5,004,100–5,004,789 | at TSS | At TSS | 140 | |
| chr18:5,196,239–5,197,482 | 192.6 kb | Distal (>10kb) Multiome | 472 | |
| chr18:5,237,139–5,238,880 | 233.5 kb | Distal (>10kb) Multiome | 958 | |
| chr18:5,294,279–5,297,100 | 291.7 kb | Distal (>10kb) Multiome | 946 |
Genomic view of the ENSG00000266268 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.