Transcription factors with Perturb-seq knockdown data for ENSG00000264015. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000264015 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000264015, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr18:77,131,704–77,133,800 | 288.8 kb | Distal (>10kb) Multiome | 561 | |
| chr18:77,249,343–77,251,937 | 171.8 kb | Distal (>10kb) Multiome | 221 | |
| chr18:77,421,584–77,422,025 | at TSS | At TSS | 4 | |
| chr18:77,530,402–77,531,211 | 109.2 kb | Distal (>10kb) Multiome | 152 |
Genomic view of the ENSG00000264015 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.