Transcription factors with Perturb-seq knockdown data for ENSG00000263272. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000263272 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000263272, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:5,191,578–5,192,305 | 241.0 kb | Distal (>10kb) Multiome | 771 | |
| chr17:5,281,614–5,283,116 | 150.6 kb | Distal (>10kb) Multiome | 705 | |
| chr17:5,419,157–5,420,471 | 13.0 kb | Distal (>10kb) Multiome | 891 | |
| chr17:5,438,801–5,439,554 | 6.3 kb | Proximal (<10kb) Multiome | 889 | |
| chr17:5,468,372–5,469,379 | 36.1 kb | Distal (>10kb) Multiome | 890 | |
| chr17:5,485,725–5,487,042 | 53.5 kb | Distal (>10kb) Multiome | 951 | |
| chr17:5,500,534–5,501,338 | 68.2 kb | Distal (>10kb) Multiome | 489 |
Genomic view of the ENSG00000263272 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.