Transcription factors with Perturb-seq knockdown data for ENSG00000261799. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000261799 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000261799, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:114,410–115,115 | 162.3 kb | Distal (>10kb) Multiome | 103 | |
| chr12:188,514–189,385 | 87.9 kb | Distal (>10kb) Multiome | 399 | |
| chr12:203,433–204,150 | 73.3 kb | Distal (>10kb) Multiome | 173 | |
| chr12:219,759–220,243 | 57.1 kb | Distal (>10kb) Multiome | 454 | |
| chr12:253,958–254,560 | 22.8 kb | Distal (>10kb) Multiome HiCAR | 30 | |
| chr12:459,530–460,568 | 182.8 kb | Distal (>10kb) Multiome | 338 | |
| chr12:509,461–510,940 | 233.3 kb | Distal (>10kb) Multiome | 399 | |
| chr12:569,602–571,188 | 292.8 kb | Distal (>10kb) Multiome | 800 |
Genomic view of the ENSG00000261799 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.