Transcription factors with Perturb-seq knockdown data for ENSG00000261526. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000261526 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000261526, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:1,592,085–1,593,444 | 283.4 kb | Distal (>10kb) Multiome | 883 | |
| chr19:1,604,859–1,606,501 | 270.5 kb | Distal (>10kb) Multiome | 902 | |
| chr19:1,651,519–1,653,514 | 223.2 kb | Distal (>10kb) Multiome | 909 | |
| chr19:1,725,307–1,726,101 | 150.4 kb | Distal (>10kb) Multiome | 455 | |
| chr19:1,811,638–1,813,347 | 63.6 kb | Distal (>10kb) Multiome | 782 | |
| chr19:1,826,853–1,827,379 | 49.0 kb | Distal (>10kb) Multiome | 193 | |
| chr19:1,848,048–1,848,953 | 27.5 kb | Distal (>10kb) Multiome | 819 | |
| chr19:1,851,701–1,852,216 | 24.2 kb | Distal (>10kb) Multiome | 115 | |
| chr19:1,855,082–1,856,620 | 20.7 kb | Distal (>10kb) Multiome | 476 | |
| chr19:1,861,439–1,865,723 | 11.1 kb | Distal (>10kb) Multiome | 891 | |
| chr19:1,871,279–1,871,530 | 4.7 kb | Proximal (<10kb) | 435 | |
| chr19:1,875,645–1,876,693 | 58 bp | At TSS Multiome | 887 | |
| chr19:1,877,235–1,877,541 | 1.0 kb | Proximal (<10kb) | 7 | |
| chr19:1,885,058–1,885,861 | 9.3 kb | Proximal (<10kb) Multiome | 495 | |
| chr19:1,904,556–1,906,084 | 29.2 kb | Distal (>10kb) Multiome | 907 | |
| chr19:1,940,240–1,942,987 | 64.8 kb | Distal (>10kb) Multiome | 901 | |
| chr19:2,034,637–2,035,967 | 158.9 kb | Distal (>10kb) Multiome | 368 | |
| chr19:2,041,744–2,042,811 | 166.0 kb | Distal (>10kb) Multiome | 586 | |
| chr19:2,049,171–2,052,365 | 175.1 kb | Distal (>10kb) Multiome | 977 | |
| chr19:2,060,703–2,062,560 | 185.4 kb | Distal (>10kb) Multiome | 913 | |
| chr19:2,095,898–2,097,954 | 220.5 kb | Distal (>10kb) Multiome | 945 | |
| chr19:2,150,726–2,152,200 | 275.5 kb | Distal (>10kb) Multiome | 761 | |
| chr19:2,163,561–2,164,587 | 287.7 kb | Distal (>10kb) Multiome | 750 |
Genomic view of the ENSG00000261526 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.