Transcription factors with Perturb-seq knockdown data for ENSG00000260167. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000260167 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000260167, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:30,334,526–30,335,777 | 250.6 kb | Distal (>10kb) Multiome | 486 | |
| chr16:30,354,854–30,355,978 | 230.5 kb | Distal (>10kb) Multiome | 1070 | |
| chr16:30,369,220–30,371,611 | 215.1 kb | Distal (>10kb) Multiome | 818 | |
| chr16:30,377,495–30,379,532 | 207.5 kb | Distal (>10kb) Multiome | 1025 | |
| chr16:30,394,422–30,396,098 | 190.7 kb | Distal (>10kb) Multiome | 941 | |
| chr16:30,400,026–30,401,048 | 185.4 kb | Distal (>10kb) Multiome | 839 | |
| chr16:30,406,974–30,408,429 | 178.4 kb | Distal (>10kb) Multiome | 908 | |
| chr16:30,417,414–30,418,576 | 167.8 kb | Distal (>10kb) Multiome | 543 | |
| chr16:30,429,571–30,430,773 | 155.7 kb | Distal (>10kb) Multiome HiCAR | 1060 | |
| chr16:30,445,340–30,446,062 | 140.1 kb | Distal (>10kb) Multiome | 898 | |
| chr16:30,526,068–30,527,896 | 58.5 kb | Distal (>10kb) Multiome | 1004 | |
| chr16:30,534,370–30,535,460 | 51.0 kb | Distal (>10kb) Multiome HiCAR | 957 | |
| chr16:30,557,913–30,558,847 | 27.4 kb | Distal (>10kb) Multiome | 1025 | |
| chr16:30,571,001–30,572,505 | 13.9 kb | Distal (>10kb) Multiome | 950 | |
| chr16:30,585,243–30,586,223 | 100 bp | At TSS Multiome | 588 | |
| chr16:30,609,586–30,610,748 | 24.5 kb | Distal (>10kb) Multiome | 1030 | |
| chr16:30,634,070–30,634,986 | 48.5 kb | Distal (>10kb) Multiome | 907 | |
| chr16:30,650,029–30,651,831 | 64.8 kb | Distal (>10kb) Multiome | 992 | |
| chr16:30,657,638–30,659,894 | 72.4 kb | Distal (>10kb) Multiome | 1053 | |
| chr16:30,677,814–30,678,622 | 92.3 kb | Distal (>10kb) Multiome | 177 | |
| chr16:30,697,755–30,699,614 | 113.2 kb | Distal (>10kb) Multiome | 1153 | |
| chr16:30,747,864–30,748,943 | 162.5 kb | Distal (>10kb) Multiome | 824 | |
| chr16:30,761,380–30,762,606 | 176.3 kb | Distal (>10kb) Multiome | 885 | |
| chr16:30,774,965–30,776,186 | 189.6 kb | Distal (>10kb) Multiome | 1025 | |
| chr16:30,786,385–30,788,019 | 201.3 kb | Distal (>10kb) Multiome | 885 | |
| chr16:30,805,468–30,806,187 | 219.8 kb | Distal (>10kb) Multiome | 969 | |
| chr16:30,814,045–30,814,733 | 228.6 kb | Distal (>10kb) Multiome | 995 | |
| chr16:30,841,062–30,841,882 | 255.7 kb | Distal (>10kb) Multiome | 49 | |
| chr16:30,874,866–30,875,643 | 289.4 kb | Distal (>10kb) Multiome | 1108 |
Genomic view of the ENSG00000260167 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.