Transcription factors with Perturb-seq knockdown data for ENSG00000259985. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000259985 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000259985, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr18:31,681,283–31,681,462 | 4.2 kb | Proximal (<10kb) | 38 | |
| chr18:31,684,202–31,686,118 | at TSS | At TSS | 718 | |
| chr18:31,686,804–31,687,500 | 1.1 kb | Proximal (<10kb) | 102 | |
| chr18:31,688,746–31,688,908 | 3.1 kb | Proximal (<10kb) | 43 |
Genomic view of the ENSG00000259985 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.