Transcription factors with Perturb-seq knockdown data for ENSG00000259865. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000259865 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000259865, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:246,931,032–246,932,682 | 256.5 kb | Distal (>10kb) Multiome | 1007 | |
| chr1:247,007,420–247,008,623 | 180.5 kb | Distal (>10kb) Multiome | 629 | |
| chr1:247,078,252–247,079,771 | 109.7 kb | Distal (>10kb) Multiome | 817 | |
| chr1:247,089,108–247,090,336 | 98.8 kb | Distal (>10kb) Multiome | 197 | |
| chr1:247,103,830–247,105,264 | 84.1 kb | Distal (>10kb) Multiome | 878 | |
| chr1:247,110,957–247,112,601 | 76.4 kb | Distal (>10kb) Multiome | 790 | |
| chr1:247,118,927–247,119,515 | 69.4 kb | Distal (>10kb) Multiome | 252 | |
| chr1:247,210,163–247,211,257 | 22.3 kb | Distal (>10kb) Multiome | 764 | |
| chr1:247,330,646–247,333,480 | 143.4 kb | Distal (>10kb) Multiome | 839 | |
| chr1:247,347,704–247,348,357 | 159.5 kb | Distal (>10kb) Multiome | 165 | |
| chr1:247,356,823–247,358,156 | 168.7 kb | Distal (>10kb) Multiome | 296 | |
| chr1:247,376,539–247,377,867 | 188.4 kb | Distal (>10kb) Multiome | 164 | |
| chr1:247,389,944–247,390,543 | 201.8 kb | Distal (>10kb) Multiome | 451 | |
| chr1:247,448,083–247,448,740 | 259.9 kb | Distal (>10kb) Multiome | 246 |
Genomic view of the ENSG00000259865 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.