Transcription factors with Perturb-seq knockdown data for ENSG00000259514. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000259514 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000259514, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:76,333,950–76,334,254 | 7.8 kb | Proximal (<10kb) | 330 | |
| chr15:76,335,050–76,335,692 | 6.4 kb | Proximal (<10kb) | 187 | |
| chr15:76,335,834–76,337,186 | 4.9 kb | Proximal (<10kb) | 781 | |
| chr15:76,337,664–76,338,596 | 3.5 kb | Proximal (<10kb) | 603 | |
| chr15:76,339,679–76,340,052 | 2.0 kb | Proximal (<10kb) | 92 | |
| chr15:76,340,219–76,340,942 | 1.1 kb | Proximal (<10kb) | 139 | |
| chr15:76,341,048–76,343,196 | at TSS | At TSS | 257 | |
| chr15:76,345,613–76,346,889 | 3.5 kb | Proximal (<10kb) | 577 | |
| chr15:76,347,025–76,347,456 | 5.0 kb | Proximal (<10kb) | 187 |
Genomic view of the ENSG00000259514 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.