Transcription factors with Perturb-seq knockdown data for ENSG00000258603. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000258603 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000258603, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:73,457,486–73,459,145 | 175.0 kb | Distal (>10kb) Multiome | 720 | |
| chr14:73,490,604–73,491,982 | 142.7 kb | Distal (>10kb) Multiome | 866 | |
| chr14:73,569,145–73,570,199 | 64.3 kb | Distal (>10kb) Multiome | 680 | |
| chr14:73,591,810–73,592,493 | 41.6 kb | Distal (>10kb) Multiome | 259 | |
| chr14:73,612,266–73,613,237 | 21.1 kb | Distal (>10kb) Multiome | 521 | |
| chr14:73,633,521–73,634,788 | 100 bp | At TSS Multiome | 541 | |
| chr14:73,644,535–73,645,291 | 11.2 kb | Distal (>10kb) Multiome | 667 | |
| chr14:73,713,545–73,714,769 | 80.6 kb | Distal (>10kb) Multiome | 759 | |
| chr14:73,718,770–73,719,334 | 85.4 kb | Distal (>10kb) Multiome | 138 | |
| chr14:73,759,247–73,760,633 | 126.6 kb | Distal (>10kb) Multiome | 912 | |
| chr14:73,771,644–73,772,269 | 138.3 kb | Distal (>10kb) Multiome | 846 | |
| chr14:73,785,281–73,785,818 | 151.8 kb | Distal (>10kb) Multiome | 458 | |
| chr14:73,786,685–73,787,517 | 153.5 kb | Distal (>10kb) Multiome | 497 | |
| chr14:73,851,491–73,852,843 | 218.2 kb | Distal (>10kb) Multiome | 842 | |
| chr14:73,886,331–73,887,426 | 253.1 kb | Distal (>10kb) Multiome | 963 |
Genomic view of the ENSG00000258603 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.