Transcription factors with Perturb-seq knockdown data for ENSG00000258131. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000258131 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000258131, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:96,906,645–96,908,185 | 78.3 kb | Distal (>10kb) Multiome | 872 | |
| chr12:96,985,502–96,986,307 | 109 bp | At TSS Multiome | 311 | |
| chr12:96,987,028–96,987,277 | 1.4 kb | Proximal (<10kb) | 105 | |
| chr12:96,988,214–96,988,367 | 2.6 kb | Proximal (<10kb) | 7 | |
| chr12:97,131,381–97,132,173 | 146.1 kb | Distal (>10kb) Multiome | 206 | |
| chr12:97,396,794–97,397,554 | 411.5 kb | Distal (>10kb) Multiome HiCAR | 136 | |
| chr12:98,397,273–98,398,042 | 1412.0 kb | Distal (>10kb) Multiome HiCAR | 455 | |
| chr12:98,456,620–98,457,422 | 1471.4 kb | Distal (>10kb) Multiome HiCAR | 319 |
Genomic view of the ENSG00000258131 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.