Transcription factors with Perturb-seq knockdown data for ENSG00000257474. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000257474 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000257474, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:79,532,720–79,533,075 | 7.1 kb | Proximal (<10kb) | 161 | |
| chr12:79,534,249–79,535,297 | 4.9 kb | Proximal (<10kb) | 67 | |
| chr12:79,541,420–79,541,731 | 1.2 kb | Proximal (<10kb) | 3 | |
| chr12:79,547,112–79,548,307 | 6.9 kb | Proximal (<10kb) | 725 |
Genomic view of the ENSG00000257474 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.