This locus represents naturally occurring read-through transcription between the neighboring HOXA10 (homeobox A10) and HOXA9 (full description written out) genes on chromosome 7. The read-through transcript is a candidate for nonsense-mediated mRNA decay (NMD), and is unlikely to produce a protein product. [provided by RefSeq, Mar 2011]
Transcription factors with Perturb-seq knockdown data for ENSG00000257184. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000257184 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000257184, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:27,169,371–27,170,025 | 10.0 kb | Proximal (<10kb) | 215 | |
| chr7:27,171,388–27,171,582 | 8.4 kb | Proximal (<10kb) | 154 | |
| chr7:27,173,233–27,174,630 | 5.4 kb | Proximal (<10kb) | 329 | |
| chr7:27,175,708–27,176,093 | 3.9 kb | Proximal (<10kb) | 88 | |
| chr7:27,179,593–27,180,372 | at TSS | At TSS | 400 | |
| chr7:27,182,906–27,183,713 | 2.9 kb | Proximal (<10kb) | 168 | |
| chr7:27,184,386–27,185,008 | 4.4 kb | Proximal (<10kb) | 294 | |
| chr7:27,189,272–27,189,665 | 9.3 kb | Proximal (<10kb) | 103 |
Genomic view of the ENSG00000257184 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.