Transcription factors with Perturb-seq knockdown data for ENSG00000257060. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000257060 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000257060, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:92,808,119–92,810,229 | 280.1 kb | Distal (>10kb) Multiome | 1196 | |
| chr15:92,820,255–92,820,821 | 268.9 kb | Distal (>10kb) Multiome | 703 | |
| chr15:92,831,519–92,832,242 | 257.4 kb | Distal (>10kb) Multiome | 904 | |
| chr15:92,881,916–92,883,525 | 206.8 kb | Distal (>10kb) Multiome | 906 | |
| chr15:92,899,945–92,900,660 | 189.1 kb | Distal (>10kb) Multiome | 712 | |
| chr15:92,903,883–92,904,823 | 185.0 kb | Distal (>10kb) Multiome | 1080 | |
| chr15:93,029,697–93,031,417 | 58.6 kb | Distal (>10kb) Multiome | 387 | |
| chr15:93,072,427–93,074,030 | 16.2 kb | Distal (>10kb) Multiome | 430 | |
| chr15:93,087,724–93,089,709 | 92 bp | At TSS Multiome | 499 | |
| chr15:93,236,114–93,237,540 | 147.8 kb | Distal (>10kb) Multiome HiCAR | 241 | |
| chr15:93,264,156–93,264,841 | 174.9 kb | Distal (>10kb) Multiome HiCAR | 90 | |
| chr15:93,331,353–93,332,146 | 242.4 kb | Distal (>10kb) Multiome HiCAR | 316 | |
| chr15:93,418,389–93,419,134 | 329.4 kb | Distal (>10kb) Multiome HiCAR | 121 | |
| chr15:93,829,073–93,830,901 | 740.4 kb | Distal (>10kb) Multiome HiCAR | 379 | |
| chr15:94,126,833–94,127,772 | 1037.9 kb | Distal (>10kb) Multiome HiCAR | 42 |
Genomic view of the ENSG00000257060 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.