Transcription factors with Perturb-seq knockdown data for ENSG00000256923. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000256923 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000256923, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:22,443,250–22,443,763 | 299.0 kb | Distal (>10kb) Multiome | 286 | |
| chr12:22,543,368–22,545,088 | 198.0 kb | Distal (>10kb) Multiome | 1040 | |
| chr12:22,624,339–22,626,265 | 117.5 kb | Distal (>10kb) Multiome | 1049 | |
| chr12:22,699,795–22,700,629 | 42.7 kb | Distal (>10kb) Multiome | 93 | |
| chr12:22,700,769–22,701,762 | 41.3 kb | Distal (>10kb) Multiome | 149 | |
| chr12:22,858,644–22,859,647 | 116.6 kb | Distal (>10kb) Multiome | 205 | |
| chr12:22,915,885–22,917,073 | 173.8 kb | Distal (>10kb) Multiome | 125 | |
| chr12:22,924,088–22,924,950 | 181.9 kb | Distal (>10kb) Multiome | 60 | |
| chr12:22,925,485–22,926,247 | 183.4 kb | Distal (>10kb) Multiome | 84 |
Genomic view of the ENSG00000256923 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.