Transcription factors with Perturb-seq knockdown data for ENSG00000255921. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000255921 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000255921, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:24,946,593–24,946,746 | 2.4 kb | Proximal (<10kb) | 176 | |
| chr12:24,946,968–24,947,430 | 1.7 kb | Proximal (<10kb) | 383 | |
| chr12:24,948,286–24,949,505 | at TSS | At TSS | 834 | |
| chr12:24,950,116–24,950,798 | 954 bp | At TSS | 257 | |
| chr12:24,951,712–24,952,252 | 2.5 kb | Proximal (<10kb) | 314 | |
| chr12:24,953,929–24,954,769 | 4.8 kb | Proximal (<10kb) | 128 | |
| chr12:24,955,963–24,956,281 | 6.8 kb | Proximal (<10kb) | 27 |
Genomic view of the ENSG00000255921 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.