Transcription factors with Perturb-seq knockdown data for ENSG00000255240. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000255240 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000255240, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:58,900,167–58,901,350 | 157.5 kb | Distal (>10kb) Multiome | 303 | |
| chr11:58,905,068–58,906,400 | 152.6 kb | Distal (>10kb) Multiome | 397 | |
| chr11:58,926,958–58,929,011 | 130.9 kb | Distal (>10kb) Multiome | 272 | |
| chr11:58,963,030–58,964,168 | 94.7 kb | Distal (>10kb) Multiome | 243 | |
| chr11:59,053,414–59,053,615 | 4.8 kb | Proximal (<10kb) | 6 | |
| chr11:59,058,072–59,058,928 | 93 bp | At TSS Multiome | 236 | |
| chr11:59,101,879–59,102,715 | 43.9 kb | Distal (>10kb) Multiome | 199 | |
| chr11:59,106,296–59,108,091 | 48.5 kb | Distal (>10kb) Multiome | 495 | |
| chr11:59,142,370–59,143,459 | 84.5 kb | Distal (>10kb) Multiome | 736 | |
| chr11:59,144,606–59,145,343 | 86.5 kb | Distal (>10kb) Multiome | 528 | |
| chr11:59,171,483–59,174,527 | 113.5 kb | Distal (>10kb) Multiome | 865 |
Genomic view of the ENSG00000255240 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.