Transcription factors with Perturb-seq knockdown data for ENSG00000254787. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000254787 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000254787, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:84,436,900–84,438,370 | 283.1 kb | Distal (>10kb) Multiome | 287 | |
| chr11:84,648,251–84,648,918 | 72.2 kb | Distal (>10kb) Multiome | 126 | |
| chr11:84,714,358–84,714,571 | 6.3 kb | Proximal (<10kb) | 361 | |
| chr11:84,719,746–84,721,467 | 36 bp | At TSS Multiome | 359 | |
| chr11:84,722,699–84,723,115 | 1.9 kb | Proximal (<10kb) | 29 | |
| chr11:84,730,619–84,731,459 | 9.8 kb | Proximal (<10kb) | 19 | |
| chr11:85,627,372–85,629,061 | 907.6 kb | Distal (>10kb) Multiome HiCAR | 826 |
Genomic view of the ENSG00000254787 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.