Transcription factors with Perturb-seq knockdown data for ENSG00000254297. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000254297 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000254297, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:167,294,984–167,295,162 | 8.2 kb | Proximal (<10kb) | 171 | |
| chr5:167,296,738–167,296,950 | 6.4 kb | Proximal (<10kb) | 87 | |
| chr5:167,300,286–167,301,133 | 2.2 kb | Proximal (<10kb) | 6 | |
| chr5:167,301,790–167,302,165 | 1.2 kb | Proximal (<10kb) | 26 | |
| chr5:167,305,858–167,306,335 | 2.5 kb | Proximal (<10kb) | 54 |
Genomic view of the ENSG00000254297 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.