Transcription factors with Perturb-seq knockdown data for ENSG00000254186. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000254186 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000254186, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:162,067,189–162,069,001 | 1368.7 kb | Distal (>10kb) Multiome HiCAR | 348 | |
| chr5:162,274,142–162,276,042 | 1161.5 kb | Distal (>10kb) Multiome HiCAR | 297 | |
| chr5:162,279,851–162,281,314 | 1156.4 kb | Distal (>10kb) Multiome HiCAR | 87 | |
| chr5:163,273,656–163,274,943 | 163.0 kb | Distal (>10kb) Multiome | 149 | |
| chr5:163,330,258–163,331,560 | 106.3 kb | Distal (>10kb) Multiome | 240 | |
| chr5:163,334,244–163,334,828 | 102.8 kb | Distal (>10kb) Multiome | 66 | |
| chr5:163,340,037–163,340,700 | 96.9 kb | Distal (>10kb) Multiome | 37 | |
| chr5:163,432,842–163,434,227 | 3.8 kb | Proximal (<10kb) Multiome | 173 | |
| chr5:163,436,410–163,436,897 | 395 bp | At TSS | 63 | |
| chr5:163,437,029–163,438,386 | 272 bp | At TSS Multiome | 946 | |
| chr5:163,459,472–163,462,155 | 23.1 kb | Distal (>10kb) Multiome | 1131 | |
| chr5:163,502,571–163,503,862 | 65.9 kb | Distal (>10kb) Multiome | 479 | |
| chr5:163,505,139–163,506,032 | 68.3 kb | Distal (>10kb) Multiome | 889 | |
| chr5:163,531,300–163,534,247 | 94.2 kb | Distal (>10kb) Multiome | 391 |
Genomic view of the ENSG00000254186 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.