Transcription factors with Perturb-seq knockdown data for ENSG00000253706. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000253706 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000253706, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:74,349,958–74,351,029 | 516.5 kb | Distal (>10kb) Multiome HiCAR | 920 | |
| chr8:74,605,838–74,606,352 | 260.8 kb | Distal (>10kb) Multiome | 104 | |
| chr8:74,866,712–74,867,151 | at TSS | At TSS | 58 | |
| chr8:74,983,972–74,985,416 | 117.6 kb | Distal (>10kb) Multiome | 443 |
Genomic view of the ENSG00000253706 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.