Transcription factors with Perturb-seq knockdown data for ENSG00000253636. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000253636 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000253636, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:72,972,189–72,972,746 | 79.6 kb | Distal (>10kb) Multiome | 126 | |
| chr8:73,008,165–73,009,389 | 43.4 kb | Distal (>10kb) Multiome | 699 | |
| chr8:73,092,506–73,093,728 | 41.0 kb | Distal (>10kb) Multiome | 249 | |
| chr8:73,174,013–73,174,795 | 122.3 kb | Distal (>10kb) Multiome | 447 | |
| chr8:73,285,133–73,286,577 | 233.7 kb | Distal (>10kb) Multiome | 282 | |
| chr8:73,293,182–73,296,152 | 242.0 kb | Distal (>10kb) Multiome | 1030 |
Genomic view of the ENSG00000253636 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.